Endocrine Abstracts

Background: Primary aldosteronism is associated with increased vascular mortality and morbidity.Aims: We aimed to assess metabolic and hormonal profile differences in patients with primary aldosteronism (PA) compared with patients with essential hypertension (EH).Patients and methods: Thirty-one patients (11 M/20 F) with primary aldosteronism, aged 46.2±12.9 years and 64 patients (24 M/40 F) with essential hypertension, aged 4...

Background: Diabetes mellitus is a metabolic disease associated with an increased risk of fracture, despite normal or increased bone mineral density (BMD), especially type 2 diabetes mellitus (T2DM). Trabecular bone score (TBS) is an imaging investigation that measures the grayscale variations on the lumbar spine performed on the DXA machine. The aim of this study was to evaluate the determinants associated with low BMD and TBS in patients with type 1 and type 2 diabetes melli...

Introduction: Sox2 is a widely expressed marker of progenitor and stem cells in various organs, strongly expressed within Rathke’s pouch and the neural ectoderm. It exerts a critical role in the early stages of pituitary development but it is still expressed in the adult gland. Sox2 expression in pituitary adenomas and its possible correlation with clinicopathologic characteristics have not been investigated so far.Aim: To evaluate the immunohistoch...

BackgroundFluid balance in patients with diabetes insipidus and COVID-19 is very fragile. The prevalence of hyponatraemia in patients with pneumonia due to COVID-19 seems to be low, but in patients admitted to intensive care units (ICU) is high (up to 20.5%). In contrast, hypernatraemia may also develop in COVID-19 patients in ICU (up to 3.7% of cases), due to insensible water losses from pyrexia, increased respiration rate and use of diuretics. Both hyp...

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

Background: PTH is a hormone with vascular and cardiovascular properties, involved in the expression of endothelial pro-atherosclerotic and pro-inflammatory parameters. Both hypercalcemic and normocalcemic primary hyperparathyroidism (PHPT) were associated with increased cardiovascular risk.Patients and methods: 84 patients (6M/78F) with PHPT, aged 58.9±12.7 years, were retrospectively reviewed. Serum calcium levels, PTH and 25 OH vitamin D levels w...

Background: Osteoporosis is a chronic metabolic bone disease, highly prevalent in the elderly population, especially in postmenopausal women. Denosumab is a potent anti-resorptive drug, which can be used as an initial therapy or as an alternative therapy in the treatment of osteoporosis.Objective: We aimed to analyze the characteristics of patients, the evolution of bone mass density (BMD) and trabecular bone score (TBS) and the factors associated with f...

Introduction: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor derived from C cells that is responsible for approximately 5% of the gland malignancies, most of them occuring sporadically. Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic factor. Surgery is the only curative therapy while other chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostat...

Background: Excess mortality after hip fracture remains a problem of public health concern. Until present, for Romania no data is available regarding long term mortality rate and excess mortality after hip fracture. We aimed to evaluate the mortality rate 3 years after hip fracture and also standardized mortality rates of osteoporotic hip fracture in the capital city of Romania and suburban area.Methods: we collected data from over 98 % of fractures admi...